Molecular glues are revolutionizing cancer therapy by targeting undruggable proteins for degradation, enhancing precision ...

CNRS UMR 6061, Institute of Genetics & Development, University of Rennes 1, Mitosis & Meiosis Group, IFR 140 GFAS, 35 043 Rennes Cedex, France, Health and Environment Unit, Laval University Medical ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...

Ubiquitin is a small protein consisting of 76 amino acids that binds to lysine residues of substrates, usually by a combination of three enzymes: a ubiquitin-activating enzyme (E1, two types), a ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. VE-cadherin is a major component of the cell ...

Proteins are more than just important nutritional units to track in your diet. They are encoded into our DNA and are the building blocks of all living things, making up everything from the lettuce ...

Zhihui Song, Wei Wei, Wenming Xiao, Essel D. Al-Saleem, Reza Nejati, Liqi Chen, Jiejing Yin, Joseph Fabrizio, Michael N. Petrus, Thomas A. Waldmann, Yibin Yang Proceedings of the National Academy of ...

Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which ...

Nedd4/Rsp5 family E3 ligases mediate numerous cellular processes, many of which require the E3 ligase to interact with PY motif containing adaptor proteins. Several arrestin-related trafficking ...

(A) PknG catalyzes a two‐step ubiquitination reaction which starts by binding to UbcH7 and transferring Ub to the E2 to form UbcH7K82‐Ub in a process energized by ATP. Second, PknG catalyzes the ...