Agios Pharmaceuticals AGIO announced that the FDA has not yet given its decision related to the company’s supplemental new ...

Agios Pharmaceuticals has seen its fair value estimate cut from roughly $42.33 to about $32.13 per share, as analysts recalibrate expectations following mixed clinical outcomes and a more uncertain ...

Topline results from the RISE UP phase 3 trial demonstrated that mitapivat significantly improved hemoglobin response in patients with sickle cell disease.

A naturally occurring metabolic compound, pyruvate, has been identified as a potent suppressor of inflammation in ulcerative colitis (UC), offering a promising new strategy for treating this chronic ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

This study presents a valuable finding on the importance of the plasma metabolome in glaucoma risk prediction. The evidence supporting the claims of the authors is solid and the work offers insights ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...

Scientists have cracked the structure of the mitochondrial pyruvate carrier, a fuel gate inside our cells, after 50 years of speculation. The discovery could revolutionize treatment strategies for ...

The purpose of this study was to investigate whether circulating pyruvate kinase M2 (PK‐M2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in ...

Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...

Use of Sodium Thiosulfate as an Otoprotectant in Patients With Cancer Treated With Platinum Compounds: A Review of the Literature In 2020, ASCO published a guideline on the selection of optimal ...