Researchers at the Department of Cell and Molecular Biology, Karolinska Institutet have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

Norovirus is the leading cause of gastroenteritis and is responsible for hundreds of thousands of deaths every year. However, ...

How can a virus with only five proteins dominate a human cell that contains thousands? This question has long puzzled ...

The universal features that define genomic regions acting as replication origins remain unclear. In this study, we mapped a set of origins in Trypanosoma brucei using stranded short nascent strand ...

Since the human immunodeficiency virus (HIV) was identified in 1983, roughly 91.4 million people around the world have ...

Background Chronic hepatitis B virus (HBV) infection disproportionately affects people living with HIV, who are often excluded from functional cure studies. Objective This study investigates CD8+ T ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints ...

Technologies needed for tracing engineered biothreats back to their sources are advancing rapidly. Here are some ...

While many plant viruses cause diseases that reduce crop yield, quality, and overall plant health, not all viruses are purely detrimental. Under certain conditions, some can confer beneficial effects, ...

A collaborative study by scientists at the University of California, Riverside, and University of Southern California reports on how a process known as alternative splicing, often described as ...

Ancient viral fossils buried in our DNA are offering fresh clues about how today’s respiratory pathogens infect and spread. By tracing the shared architecture between long-extinct retroviruses and ...

Cryo-EM revealed HIV-1 integrase’s distinct structures as it shifts between its two roles of DNA integration and RNA-binding.