When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical ...
The EIT–EVA PCB sensor setup used to evaluate the effects of drugs on hERG channels. The sensor measures changes in extracellular resistance as voltage-gated hERG channels are activated and inhibited, ...
Repolarization abbreviation with the antiarrhythmic drug mexiletine has been found to normalize the QTc interval and reduce the rate of events in long QT syndrome type 3 (LQT3), but it is only ...
Currently, only 10% of the drugs that enter Phase I receive marketing approval from the U.S. Food and Drug Administration (FDA), with unmanageable toxicity accounting for approximately 30% of the ...
Cardiotoxicity underlies a third of failures in regulatory clearance, making it among the most significant hurdles in developing new drugs. 1 axoCells human iPSC-derived ventricular cardiomyocytes ...
The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
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