Neuronal TDP-43 pathology marks most cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but how does a single protein fit with such a wide range of symptoms? Researchers ...
In amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the usually nuclear TDP-43 wanders out into the cytoplasm, causing neurons to wither and die. What makes cytoplasmic TDP-43 so ...
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