The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

Inositol trisphosphate receptors (IP3Rs) are pivotal Ca²⁺ channels embedded in the membrane of the endoplasmic reticulum. Their activation by inositol 1,4,5-trisphosphate (IP3) and Ca²⁺ gives rise to ...

Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice. Researchers at the NYU Pain Research Center have found a new receptor for ...

Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be ...

A new review links three forces shaping osteoarthritis: mechanical stress, integrin signaling, and integrin endocytosis. The ...

A team has demonstrated new mechanisms that are involved in the development of inflammatory cardiovascular diseases. A team led by LMU researchers Christian Weber and Yvonne Döring has demonstrated ...

Researchers found that intestinal tuft cells signal to crypt enterochromaffin cells by releasing acetylcholine, triggering serotonin release and activating a gut-to-brain vagal pathway during type 2 ...

Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma The following represents disclosure information provided by ...

Olfactory receptors (ORs), the largest family within the G protein–coupled receptor (GPCR) superfamily, have long been recognized for their essential ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

An international team, including scientists from Leipzig University, has gained important new insights into the regulation of ...

Researchers have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a new study. The findings hold ...