-REX-7117 is an oral, potent and selective STAT3 SH2 domain inhibitor, which demonstrated strong efficacy in an in vivo model of inflammatory arthritis -STAT3 inhibition does not impair the interferon ...
--In a preclinical model of psoriasis, the efficacy of oral small molecule REX-7117 was comparable to an anti-IL-17A biologic SAN DIEGO, May 17, 2024 (GLOBE NEWSWIRE) -- Recludix Pharma, a leader in ...
HOUSTON, Sept. 9, 2024 /PRNewswire/ -- Moleculin Biotech, Inc. (MBRX), ("Moleculin" or the "Company), a Phase 3 clinical-stage pharmaceutical company with a broad portfolio of drug candidates ...
Vividion Therapeutics Inc. has patented 2-azaspiro [3.3]heptane derivatives acting as signal transducer and activator of transcription 3 (STAT3) inhibitors potentially useful for the treatment of ...
Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
Head and neck squamous cell carcinoma (HNSCC) is approximately the seventh most common cancer in humans with an estimated 900,000 new cases globally. As a surgeon, Jennifer Grandis, MD, a physician ...
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