Multiple myeloma (MM) is a malignant plasma cell disorder derived from a B cell clone. 1 Median survival time of untreated MM patients is less than 1 year. Treatment with alkylating agents induces a ...

Renal Cell Carcinoma Recurrence After Nephrectomy for Localized Disease: Predicting Survival From Time of Recurrence Patients underwent biopsy for determination of their lymphoma-specific Id sequence.

With around 256 million cases and more than 5 million deaths worldwide, the COVID-19 pandemic has challenged scientists and those in the medical field. Researchers are working to find effective ...

As cold and flu season ramps up, the most vulnerable among us need extra protection. Infants are among the most susceptible to respiratory complications from respiratory syncytial virus, or RSV. While ...

Idiotype means that an individual differing from immunoglobulin molecule produced by B cells whose variable region has different antigen specificity. Thus it is called idiotype. The idiotypic epitopes ...

The Clinical Implications of Basic Research series has focused on highlighting laboratory research that could lead to advances in clinical therapeutics. However, the path between the laboratory and ...

Anti-idiotypic antibodies (anti-ID Ab) are antibodies that identify and attach to the idiotypic center of other antibodies. Anti-idiotype antibodies are commonly employed in therapeutic drug ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 10, [Part 2: Biological Sciences] (Oct., 1981), pp. 6416-6420 (5 pages) The progeny of BALB/c female mice ...

The clonal immunoglobulin idiotype displayed on the surface of most malignant B cells is a patient- and tumour-specific antigen that can be used for therapeutic vaccination. Several studies have ...

Murphy and Longo (published online on Nov. 24 at NEJM.org) 1 elaborate on the possible role played by anti-idiotype antibodies in the pathogenesis of severe adverse reactions to SARS-CoV-2 infection ...