Although the pathophysiology of mesangial cells has long been considered to be the major factor in the development of glomerulosclerosis in type 1 or type 2 diabetes, more recent evidence suggests ...

Glomerulus, the fundamental filtering unit of the kidney, is an intricate network of capillaries — small blood vessels that regulate the movement of ions, water, and metabolites while maintaining ...

Kidney disease is common in adults, and testing for kidney disease is part of routine clinical practice for patients with acute or chronic illness. The initial evaluation includes determination of the ...

In patients with diabetic nephropathy, glomerulopathy is an important renal structural change. The kidney consists of four basic tissue types: vessels, glomeruli, tubules, and interstitium. Each of ...

Initially, the researchers observed the specific expression of ADGRF5 within endothelial cells that line the glomerular capillary wall. In mice with genetic knockout of ADGRF5, the GFB was affected by ...

(Upper panel) Normal podocytes: Ephrin-B1 at slit diaphragm interacts with nephrin via the extracellular site and with Par6 via the cytoplasmic site. (Lower panel) Podocytes stimulated by anti-nephrin ...

A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and ...

Dr. Eugene P. Rhee: A 74-year-old man was evaluated in the nephrology clinic of this hospital because of chronic kidney disease. The patient had been in his usual state of health when he was referred ...

The kidneys contain millions of microscopic blood vessels known as peritubular capillaries. These vessels recapture helpful nutrients like glucose and minerals and return them to your bloodstream for ...