We previously found that pediatric B-cell precursor-acute lymphoblastic leukemia (BCP-ALL) patients with rearrangements of the MLL gene display the hyperactivation of a signal transduction pathway ...

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in cellular energy homeostasis, helping in growth regulation and metabolic reprogramming in eukaryotes. The AMPK ...

Researchers at the Salk Institute report they might have solved the long-standing mystery around how the protein complex AMPK can both hinder and help cancer. The lab of Reuben Shaw, Ph.D., director ...

This graphic illustration of a study in Cell Reports shows how a molecular energy regulator in cells, AMPK, is required for astrocytic glycoses, lactate production and lactate shuttle to bio-energize ...

The basic unit of all living things is the cell – and the human body contains tens of trillions of them. Cancer can be triggered by the abnormal growth and division of just one of these, which goes on ...

Physical activity benefits diabetics and others with insulin resistance. One of the reasons is that a single bout of physical activity increases the effectiveness of insulin. Thus, physical activity ...

Nowadays, the prevalence of sedentary lifestyles and high-caloric diets leads to an imbalance between energy intake and spending. Hence, in the last decades, we have observed a significant rise in ...

Please provide your email address to receive an email when new articles are posted on . Poxel SA announced positive results for the phase 2a trial of PXL770 for the treatment of nonalcoholic ...

Most breast cancers utilize the female hormone estrogen to grow, so drug-induced estrogen deprivation is used as a treatment in many patients. However, cancer will recur in one-third of these patients ...